In heavy air they would be one of the first teams overpowered - advantage F16. I agree that the F18 is tough to beat in heavy air compared to the F16, but M/G are a light crew.
In medium air, its a toss up. Depends on crew work which is equal here (theoretical discussion).
In light air the lighter F16 would have the advantage.
I am not saying that M/G would suffer on the F18 (they'd be good on any platform), but I think they picked the right platform for their situation.