The first year I did the Tybee, I wore the drysuit from Islamorada to Tybee and was very comfortable. The 'taking a potty break' thing, even with a relief zipper, is still a bit of a time consuming, and uncomfortable thing...although you tend to not worry so much about 'missing' with so much water flying around anyway. I would often find myself holding out and arriving on the beach having to make a mad dash to a restroom.

Last year I wore the drysuit only for two days and have decided that I will wear the drysuit A) when I expect it to be quite cold or B) will be sailing in a pretty desolate area (like between Fernandina and Tybee). The drysuit is simply safer since it will extend your survivability and if a problem arises in a desolate area, I would expect one might come to appreciate that benefit.

During the other legs, I'm wearing one or two layers of fleece under a pair of bibs and breathable spray top. It's really comfortable and offers a particular benefit for relief without much fuss.